Lecture on HDAC Inhibitors
James Rusche, PhD, Sr. Vice President, Research and Development, Repligen Corporation, discusses the work his company has done to identify development...
Ubiquitin signalling.
Proteins are targeted for degradation by the proteasome with covalent modification of a lysine residue that requires the coordinated reactions of...
SMRT DNA Sequencing
Pacific biosciences is developing a transformed DNA sequencing technology, which will revolutionize the field of genetic analysis by enabling researchers to...
Effux pumps
Active efflux is a mechanism responsible for extrusion of toxic substances and antibiotics outside the cell; this is considered to be...
Blastocyst Formation Video
The morula is a solid ball of about 16 undifferentiated, spherical cells. As cell division continues in the morula, the blastomeres...
CTLA-4 and Mechanism of action of anti-CTLA4
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152 (Cluster of differentiation 152) is a protein that plays an important regulatory...
Leading vs. Lagging strand replication
Leading strand The leading strand is the template strand of the DNA double helix so that the replication fork moves along...
Avery–MacLeod–McCarty experiment
The Avery–MacLeod–McCarty experiment was an experimental demonstration, reported in 1944 by Oswald Avery, Colin MacLeod, and Maclyn McCarty, that DNA is...
Nanomedicine Animation
Nanomedicine is the medical application of nanotechnology. It covers areas such as nanoparticle drug delivery and possible future applications of molecular...
Function of the Neuromuscular Junction
A neuromuscular junction (NMJ) is the synapse or junction of the axon terminal of a motoneuron with the motor end plate,...
HIV Replication Animation
Entry to the cell HIV enters macrophages and CD4+ T cells by the adsorption of glycoproteins on its surface to receptors...
Gleevecs Effects on tryosine Kinase
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Imatinib is a drug used to treat certain types of cancer. It is currently marketed by Novartis as Gleevec (USA) or...
Protein Synthesis Animation
Protein biosynthesis (Synthesis) is the process in which cells build proteins. The term is sometimes used to refer only to protein...
Actin 4 Binding region
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta...
Asparaginase
Asparaginase is an enzyme that catalyzes the hydrolysis of asparagine to aspartic acid. It is marketed under the brand name Elspar,...
Vaccines Animation
Vaccines is a biological preparation that improves immunity to a particular disease. A vaccine typically contains a small amount of an...
Bacteriorhodopsin
Bacteriorhodopsin is a protein used by archaea, most notably halobacteria. It acts as a proton pump, i.e. it captures light energy...
Preimplantation Genetic Diagnosis
Preimplantation genetic diagnosis (PGD or PIGD) (also known as embryo screening) refers to procedures that are performed on embryos prior to...
Nucleotide excision repair NER of carcinogen adducts
Nucleotide excision repair is a DNA repair mechanism. DNA constantly requires repair due to damage that can occur to bases from...
Enzyme Kinetics
Enzyme kinetics is the study of the chemical reactions that are catalysed by enzymes, with a focus on their reaction rates....
Flagellum Motar
The flagellum is linked to a flexible hook. The hook is attached to a series of protein rings , which are...
LTP Mechanisms
Long-term potentiation (LTP) is the long-lasting improvement in communication between two neurons that results from stimulating them simultaneously. Since neurons communicate...
Genome editing with engineered nucleases
Genome editing with engineered nucleases (GEEN) refers to a reverse genetics method using ‘molecular scissors’, or artificially engineered nucleases, to cut...
