Pharmacogenetics of Asthma

Pharmacogenetics offers the potential to optimize treatment for individual patients by using genetic information to improve efficacy or avoid side effects. While there are a number of examples in which the approach is already in routine clinical usage, exploitation of this approach in asthma is still under development. A number of examples of possible pharmacogenetic approaches that may prove of value in the management of asthma.

Interferons—Provoking Distinct Signals through the Same Receptor

Chris Garcia explains how the strength of the receptor-ligand interaction—not receptor conformational changes—tunes signaling duration.

BD simulation of HIV protease substrate interaction

Coarse-grained Brownian dynamics (BD) simulation for the substrate peptide- HIV protease system. Transition of the peptide substrate from an unbound to a final bound state is shown, and the protein flaps have to open to allow for the substrate binding. The total simulation length in this run was 2 microsecond.