The animation tell about,how Anti-PlGF inhibitors can be used prevents the cancerous growth
One of 4 persons will be diagnosed with cancer. In many cases current therapy does not provide an effective cure. Biologists know that normal cells divide in a highly regulated in strictly controlled manner and the cancerous tumors are formed when a cell becomes abnormal and divide without control.
Cells of the immune system are capable of detecting and killing these abnormal cells. But in cases of serious disease the rate of cancer cell divisions surpasses the effect of immune system and tumor continues to grow. In order to acquire the nutrients that necessary for growth tumor cells release of growth factors called PLGF that binds to receptors on nearby capillary blood vessels.
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This causes the capillary network to expand through the tumor provides increased blood supply and simulating tumor growth. Scientists have discovered that the process can be blocked by the administration of a small molecule called Anti-PLGF Antibody; the antibody binds to the PLGF growth factor thereby preventing associated with the Capillary vessels. This effectively blocks the expansion of capillary network and tumor growth is slowed because of limited blood supply. Because of the strong positive effect of Anti-PLGF antibodies the cancer killing cells of the immune system can now work faster than rate of cancer cell divisions
Cells of the immune system are capable of detecting and killing these abnormal cells. But in cases of serious disease the rate of cancer cell divisions surpasses the effect of immune system and tumor continues to grow. In order to acquire the nutrients that necessary for growth tumor cells release of growth factors called PLGF that binds to receptors on nearby capillary blood vessels, this causes the capillary network to expand through the tumor provides increased blood supply and simulating tumor growth. Scientists have discovered that the process can be blocked by the administration of a small molecule called Anti-PLGF Antibody; the antibody binds to the PLGF growth factor thereby preventing associated with the Capillary vessels. This effectively blocks the expansion of capillary network and tumor growth is slowed because of limited blood supply. Because of the strong positive effect of Anti-PLGF antibodies the cancer killing cells of the immune system can now work faster than rate of cancer cell divisions
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