Radial Keratotomy

Radial keratotomy (RK) is a refractive surgical procedure to correct myopia.In radial keratotomy (RK), incisions are made with a precision calibrated diamond knife. It has been found that incisions that penetrate only the superficial corneal stroma are less effective than those reaching deep into the cornea,and consequently incisions are made quite deep. One study cites incisions made to a depth equivalent to the thinnest of four corneal-thickness measurements made near the centre of the cornea. Other sources cite surgeries leaving 20 to 50 micrometres of corneal tissue unincised (roughly equivalent to 90% of corneal depth based on thickness norms).

Arcuate keratotomy is still popular to correct astigmatism. It is also done with a diamond knife but in these cases, cuts are made circumferentially, parallel to the edge of the cornea.

Postsurgical healing

Cross-section schematic of postsurgical epithelial plugs. Example of a desirable outcome left, and an undesirable outcome right.

The healing corneal wounds are comprised of newly abutting corneal stroma as well as fibroblastic cells and irregular fibrous tissue. Closer to the wound surface lies the epithelial plug, a bed of the cells that form the normal corneal epithelium, which have fallen into the wound. Often this plug is three to four times as deep as the normal corneal epithelium layer. As the cells migrate from the depth of the plug up to the surface, some die before reaching the surface, forming breaches in the otherwise healthy epithelial layer. This consequently leaves the cornea more susceptible to infection.This risk is estimated to be between 0.25%[7] and 0.7%[8] Healing of the RK incisions is very slow and unpredictable, often incomplete even years after surgery.[9] Similarly, infection of these chronic wounds can also occur years after surgery,[10][11][12] with 53% of ocular infections being 'late' in onset. The pathogen most commonly involved in such infections is the highly virulent bacterium Pseudomonas aeruginosa.