Drugs Tailored to your Genetic Makeup Lecture

Heralded as the future of medicine, personalized medicines seem to be the answer for making therapeutics more likely to be highly effective and safer. Join Deanna Kroetz of UCSF's School of Pharmacy and learn about macromolecular therapeutics, their promise, their limitations.


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Pharmacogenetics is the study or clinical testing of genetic variation that gives rise to differing response to drugs.Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in, drug metabolism with a particular emphasis on improving drug safety. The wider use of pharmacogenetic testing is viewed by many as an outstanding opportunity to improve prescribing safety and efficacy. Driving this trend are the 106,000 deaths and 2.2 Million serious events caused by adverse drug reactions in the US each year (Lazarou 1998). As such ADRs are responsible for 5-7% of hospital admissions in the US and Europe, lead to the withdrawal of 4% of new medicines and cost society an amount equal to the costs of drug treatment (Ingelman-Sundberg 2005). Comparisons of the list of drugs most commonly implicated in adverse drug reactions with the list of metabolizing enzymes with known polymorphisms found that drugs commonly involved in adverse drug reactions were also those that were metabolized by enzymes with known polymorphisms

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