Leukocyte Extravasation

Activated vascular endothelium cell express E-selectin and ICAM-1 and display chemokines on extracellular matix.leukocytes initiatly adhere by binding to selectins which recognise S-lex.these allows other molecules to bind,LFA-1 binds to ICAM-1,chemokine signalling converts this weak binding to tight adhesion.

  • The tightly bound leukocytes now migrates across the endothelium squeezing between adjacent endothelial cells.
  • Chemokine binding now signals leukocytes to migrate along the chemokine concentration gradient .
  • The site of information is the source of chemokine gradient .hence leukocytes are attracted from the blood towards sites of infection.

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