Leukocytes Rolling Adhesion

Blood vessel endothelium at site of infection expresses selectin molecule P-selectin and E-selectin.Leukocytes such as neutrophils express the ligand for selectin in form of s-Lex .The binding of endothelial selectins to s-lex is weak and cannot hold the cell against the flow of blood .instead the cell rolls on the wall of the blood vessel making and breaking many interactions with the selectins

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