Dendritic Cell Migration

Dendritic cells (DCs) are immune cells and form part of the mammalian immune system. Their main function is to process antigen material and present it on the surface to other cells of the immune system, thus functioning as antigen-presenting cells.
Dendritic cells are key presenting cells in the immune system,The are generated from Bone marrow nd migrate into proliferal tissue through the blood stream,Immature dendritic cell wait for pathogen entry(site of injury).
Dendritic cells express various pattern recognistion receptors that can recognse common features of many bacteria and fungal pathogens.Through this receptor dendritic cells bind and phagocyotsis pathogens,When this receptor bind to the pathogens the activate the dendritic cell which then starts to mature.
In this process dendritic cells migrate to the tissue and changes its behaviour to stop phagocytosis and start expressing immune stimulatory molecules
Activated dendritic cells migrate from tissue to lumphatic vessel,with lymphatic fluid drain to lymph node carrying dendritic cells with it.
T cells migrates through lymph node inspects teh dendritic cells for the presence of specific antigen.T cells which fail to recognize antigens on one dendritic cells carryon to inspect others.
T cells which recognise the specific antigen becomes activated and both proliferated and differntialte into a factor cells.

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