Hormone production is controlled by the levels of chemicals and other hormones circulating in the bloodstream. The secretion of hormones by the anterior pituitary gland is controlled by the hypothalamus of the brain and by the hormones secreted by the target glands on which the anterior pituitary hormones themselves act. The hypothalamus releases a hormone which allows the anterior pituitary to secrete its own hormone messenger. This is carried in the blood to its target endocrine gland, which is stimulated to release its hormone into the blood. The circulating target gland hormone, besides acting in the body, feeds back to the pituitary and hypothalamus to inhibit their activity. This allows a balance between the activity of the hypothalamus, the anterior pituitary and the target gland.
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